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The clinical immunology unit is the new unit that has been becoming part of clinical specialities of Ruber International Hospital, which takes care of diagnosis and treatment of pediatric patients and adults with immunological system diseases.
Our immune system protects the body against external agents (virus, bacteria, fungus or traumas) or internal agents (cancer cells). When the immune system has a deficiency in some of its elements or in its function, or a disorder in its regulation is produced, the result can be an immunodeficiency affecting its protective role against infections. Alternatively, an illness by disproportionate immune reaction in an organ, tissue or our own body system, as it occurs in the autoimmune diseases.
Immunodeficiency disorders can be inherited, as primary ones; alternatively, acquired immunodeficiency disorders, secondary to the immunosuppressing drugs administration for lasting inflammatory diseases, cancer and transplants or in virus chronic infections.
In the last decades, more than 150 primary immunodeficiency disorders have been described (PI), which identification has been possible due to the application of molecular biology techniques. The PI are frequently mistaken- or lately diagnosed, what supposes to leave the patient in a vulnerable situation to long-lasting diseases, infections, disability or organic damage. The awareness of these genetic effects has impacted decisively in early diagnosis and immunodeficiency treatment, leading to a benefit in these patients’ clinical evolution.
The reproductive immune area is a recent discipline that deals with the diagnosis and treatment of immune factors involved in the reproduction process, including fetus tolerance by the mother’s immune system. There are immune causes involved in numerous cases of repeated miscarriages, implanting failures after in vitro fertilization, premature deliveries and complications after gestation like pre-eclampsia, in that other known causes had been excluded. Depending on the immune cause, there are different therapeutic protocols to prevent the fetal death and mother’s health problems during gestation.
Clinical immunology can bring a diagnostic and therapeutic approach of complex autoimmune diseases, where reference doctors are other specialists, both for the related immune disorders early diagnosis that could benefit from an immune intervention and for the evaluation and biological therapies immune follow uptherapies immune follow up.


Diagnosis and treatment of primary immunodeficiencies

Facing suspicious symptoms as:
• Frequent infections or severes or unusuals.
• Bad response to antibiotic treatment.
• Vaccinations to immunodeficient patients.

Diagnosis and treatment of secondary immunodeficiencies

• Patients with immunosuppressive treatment or with biological therapies or infections.
• Patients with chronic diseases or associate infections.
• Vaccinations in patients in immunosuppressor treatment.

Reproductive immunology

• Primary infertility.
• Repeated failure in in vitro fertilization (IVF)
• Repeated miscarriages.

Autoimmune pathologies

• Multidisciplinary follow-up in autoimmune pathologies or complex immune base, required by the Dermatology, Neurology, Reumatology, Intern Medicine, Neumology, Ofthalmology and Ear (ORL) specialists.


Diagnostic tests

Specific immunological evaluation through genetic and immunologic techniques.

Specific treatments

Immunizations, microimmunotherapy, immune base therapies.
Day Hospital treatments and in hospital stay.